Most tumours contain hypoxic areas so that HBO is a valuable tool to reverse this phenomenon and to act as a radiosensitizer by enhancing the response to irradiation63,64.

Brizel65 measured tumour oxygenation in rats who had been implanted R3230Ac mammary adenocarcinomas during breathing NBO, normobaric carbogen, HBO at 303.9kPa (3ata) and hyperbaric carbogen at 303.9kPa (3ata). NBO or normobaric carbogen were not effective but HBO and hyperbaric carbogen improved tumour oxygenation with a rise of median PtiO2 from 8 to 55mm Hg.

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