Physiological effects of HBO for the treatment of acute necrotizing soft tissue infections

The effects of oxygen on anaerobic bacteria and on tissue infection have been reviewed in the chapter 1.6.

In summary, the rationale for the use of HBO in the treatment of acute anaerobic soft tissue infection is based on :

• a direct toxic effect of oxygen of anaerobic bacteria,

• an indirect effect of oxygen on the microbicidal capabilities of polymorphonuclears in the infected area,

• an increase in the activity of selected antibiotics.

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