Methods of tissue PO2 measurements

The ideal method should fulfill the following criteria: accuracy and reproducibility in a wide oxygen range, easy handling, safe use and non-invasiveness, limited size of the device.

In general, there are two main groups of methods available for the assessment of PtiO2: Polarographic techniques comprising tissue tonometry, transcutaneous electrodes or needle electrodes; and non-polarographic techniques comprising mass spectroscopy, near-infrared spectroscopy (NIRS), magnetic resonance spectroscopy, frozen specimen spectroscopy, positron emission tomography, electron spin resonance, NADH fluorescence, and phosphorescence quenching.

The most common methods in the clinical setting to be used under elevated ambient pressure are transcutaneous measurements, tissue tonometry and NIRS which are briefly described:

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