The use of Hyperbaric oxygen therapy (HBO) against infections started in 1961, when Brummelkamp & Boerema reported on their first successful treatment of gas gangrene in human subjects in Amsterdam1. Some years later refractory chronic osteomyelitis became another recognized indication for HBO in infectious pathology2. Over the last decades, an enormous amount of experimental and clinical research has been conducted on the effects of high pressures of oxygen on bacteria, on body's defence

mechanisms and on healing processes, enabling us to reach a better understanding of the therapeutic effects of HBO and to make a more precise assessment of clinical results. In the same time, the awareness and knowledge regarding the toxic effects of oxygen have been improved.

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