The majority of the treatment options available in clinical practice are based on animal experiments and these should be extrapolated to human pathophysiology with due caution. In animal undergoing reconstructive vascular surgery, the use of calcium channel blockers, anticoagulants, vasodilating drugs, free radical scavengers, etc. have been tested with success. Similarly, experimental and clinical research demonstrates that the administration of hyperbaric oxygen24, in certain situations, can attenuate some of the nefarious consequences of reperfusion.
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