Hyperoxic vasoconstriction

Hyperoxic vasoconstriction does not induce a decrease in oxygen delivery to the tissue, in contrast with catecholamine-induced vasoconstriction. Hyperoxic vasoconstriction causes a reduction of edema formation due to a decrease in capillary transudation. Therefore, HBO therapy is beneficial in the treatment of compartment syndrome, and also in cerebral or medullary edema. It is of paramount importance that this type of vasoconstriction only occurs in hyperoxic tissues as a protection against the development of hyperoxic lesions to decrease the risk of oxygen toxicity. It does not appear in hypoxic tissues where oxygen pressures become normal during exposure to HBO41. Vasoconstriction in a healthy area, and blood flow maintenance in an ischemic area, lead to a redistribution of blood flow to the malperfused area. The effect of HBO on features of microcirculation will be discussed in chapter 1.5.

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