Edema formation in ischemiareperfusion syndromes

Edema formation as a consequence of ischemia-reperfusion has been extensively studied in experimental compartment syndromes and flap surgery.21 Initially, ischemia induces a functional alteration of endothelial cells by the loss of their intercellular connection and energy homeostasis. Consequently, an increase in permeability of the capillary vessel wall and an increase in plasmatic filtration is observed causing interstitial edema responsible for compartment syndrome. The increase in compartmental pressure again causes ischemia as compression of blood vessels aggravates the problem of tissue hypoxia - a vicious circle.

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