Early works

Shortly after P B reported bradycardia occurring in ducks during diving and the discovery of the bradycardic reflex on immersion of the face, H , Mager & Von Schrotter (1897) described a decrease in heart rate at rest and during exercise in tubing workers exposed to pressures of 2.5 and 3.6 ata. Dautrebande & Haldane (1921), also observed bradycardia in subjects exposed to pure oxygen at 1 ata and 2 ata.

Schilling (1936) performed the first systematic study of this effect and discussed the relative importance of the various factors that could be involved: the increase in pressure of oxygen, density, hydrostatic pressure and inert gas pressure.

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