Through its direct activity on bacteria, improvement of cellular defence mechanisms of the body and synergistic effect on antibiotic activity, HBO when combined with antibiotics and surgery, is extremely useful as adjunctive therapy for treating tissue infections involving both anaerobic and aerobic bacteria in hypoxic wounds and tissues. Its usefulness has been clearly proven by a large amount of in vitro and in vivo experimental research and further confirmed by extensive clinical series. The benefit HBO provides in the field of infectious disease medicine is mostly due to the restoring of adequate, normal or above-normal pressures of oxygen in hypoxic infected tissues.

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