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PHYSIOLOGIC EFFECTS OF HYPERBARIC OXYGEN ON DNA AND DNA REPAIR -GENOTOXICITY OF HYPERBARIC OXYGEN AND ITS PREVENTION

Claude Muth1, Michael Gröger1, Peter Radermacher1, Günter Speit2

1Sektion Anaesthesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum Ulm, 89073 Ulm, Germany; Abteilung Humangenetik, Universitätsklinikum Ulm, 89070 Ulm, Germany

Abstract: HBO has a DNA-damaging and possibly mutagenic potential. In vitro studies with mammalian cells suggest that HBO-induced oxidative DNA damage mainly leads to gross genetic alterations and chromosome aberrations. Under therapeutic exposure conditions, DNA damage is detected with the comet assay, but mutations and chromosome aberrations are not observed in peripheral blood cells.

A very simple and efficient way to avoid HBO-induced DNA damage is to start with a shortened treatment before the standard protocol is applied the following days. Therefore, the hyperbaric community should think about an adaptation of the commonly used treatment protocols

Keywords: oxygen free radical, mutagenicity, DNA damage, DNA repair, antioxidant

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